Rr94^tm3.1Litt
Targeted Allele Detail

Summary

• Symbol: Rr94^tm3.1Litt
• Name: regulatory region 94; targeted mutation 3.1, Dan R Littman
• MGI ID: MGI:4452050
• Synonyms: Cd4^E4pFL, Cd4^tm3.1Litt, E4P^F
• Gene: Rr94 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr94^tm3.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158962
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region, No functional change)
• Mutation: Insertion
• Mutation details: Proximal enhancer E4p upstream of Cd4 exon 1 was flanked by a loxP site and a floxed neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette leaving the enhancer floxed. (J:158962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr94 Mutation: 0 strains or lines available

References

• Original: J:158962 Chong MM, et al., Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69
• All: 2 reference(s)