Rr112^tm4.1Litt
Targeted Allele Detail

Summary

• Symbol: Rr112^tm4.1Litt
• Name: regulatory region 112; targeted mutation 4.1, Dan R Littman
• MGI ID: MGI:4452055
• Synonyms: Cd4^tm4.1Litt, E4T^-
• Gene: Rr112 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr112^tm4.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158962
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Thymocyte enhancer E4t downstream of Cd4 (in intron 1 of Usp5) was replaced with an FRT site flanked hygromycin resistance gene cassette. Flp-mediated recombination removed the hygro cassette. Targeted ES cells carried the Rr94^tm3.1Litt allele that targets the E4p Cd4 enhancer. (J:158962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr112 Mutation: 0 strains or lines available

References

• Original: J:158962 Chong MM, et al., Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69
• All: 1 reference(s)