Pglyrp2^tm1Lky
Targeted Allele Detail

Summary

• Symbol: Pglyrp2^tm1Lky
• Name: peptidoglycan recognition protein 2; targeted mutation 1, Richard M Locksley
• MGI ID: MGI:4452065
• Gene: Pglyrp2 Location: Chr17:32631433-32643141 bp, - strand Genetic Position: Chr17, 17.56 cM
• Alliance: Pglyrp2^tm1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159600
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP construct was inserted in frame with the ATG start site followed by a floxed neomycin selection cassette. This was transfected into PC3 ES cells containing th Tg(Prm-cre)70Og transgene. The transgene is only active in male germline cells. Neomycin is thus excised in the germline. No gene expression was detected in the liver by PCR and no protein product was found in serum by Western blot. (J:159600)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pglyrp2 Mutation: 20 strains or lines available

References

• Original: J:159600 Xu M, et al., Innate immune responses in peptidoglycan recognition protein L-deficient mice. Mol Cell Biol. 2004 Sep;24(18):7949-57
• All: 2 reference(s)