Sfn^tm1Mul
Targeted Allele Detail

Summary

• Symbol: Sfn^tm1Mul
• Name: stratifin; targeted mutation 1, William J Muller
• MGI ID: MGI:4452136
• Synonyms: 14-3-3sigma^F
• Gene: Sfn Location: Chr4:133327867-133329163 bp, - strand Genetic Position: Chr4, 66.25 cM, cytoband D3
• Alliance: Sfn^tm1Mul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159517
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 434 coding base pairs of the single exon with a 5' loxP site was followed by SV40 PolyA signal with a downstream loxP site, and followed by a PGK neomycin selection cassette. Homozygous mice showed significantly reduced mRNA levels in mammary glands, although no apparent developmental or functional differences were observed. (J:159517)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfn Mutation: 15 strains or lines available

References

• Original: J:159517 Ling C, et al., A novel role for 14-3-3sigma in regulating epithelial cell polarity. Genes Dev. 2010 May;24(9):947-56
• All: 2 reference(s)