Tg(Myh6-STK4*K59R)10Jusa
Transgene Detail

Summary

• Symbol: Tg(Myh6-STK4*K59R)10Jusa
• Name: transgene insertion 10, Junichi Sadoshima
• MGI ID: MGI:4452341
• Synonyms: Tg-DN-Mst1, Tg(Myh6-MST1*K59R)10Jusa
• Transgene: Tg(Myh6-STK4*K59R)10Jusa Location: unknown
• Alliance: Tg(Myh6-STK4*K59R)10Jusa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-STK4*K59R)10Jusa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STK4 (6789)

  Stk4	(MGI:1929004)

  Transgene codes for a protein with a lysine to arginine mutation.

• Mutation details: The mouse promoter drives cardiac-specific expression of the human CDNA with nucleotide substitutions that result in the amino acid substitution of arginine for lysine at position 49 (K59R). Three lines were created (lines 9, 10, and 11) with line 10 exhibiting high expression levels and lines 9 and 11 exhibiting low expression levels. (J:139414)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:139414 Yamamoto S, et al., Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003 May;111(10):1463-74
• All: 7 reference(s)