Ightm4.1Mnz
Targeted Allele Detail
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Symbol: |
Ightm4.1Mnz |
Name: |
immunoglobulin heavy chain complex; targeted mutation 4.1, Michel C Nussenzweig |
MGI ID: |
MGI:4452369 |
Synonyms: |
IgH96k |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:159173
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
B6(Cg)-Tyrc-2J
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Insertion
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Mutation details: An frt-flanked neo cassette with 5' loxP and I-SceI site was inserted into the 3' Ighg1 switch region. Flp mediated recombination removed the neo cassette leaving the single loxP site. ES cells originally used to create this allele also contained Ightm3Mnz 96 kb upstream.
(J:159173)
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Generation of the Ightm4.1Mnz allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh Mutation: |
44 strains or lines available
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Original: |
J:159173 Bothmer A, et al., 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med. 2010 Apr 12;207(4):855-65 |
All: |
6 reference(s) |
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