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Ightm4.1Mnz
Targeted Allele Detail
Summary
Symbol: Ightm4.1Mnz
Name: immunoglobulin heavy chain complex; targeted mutation 4.1, Michel C Nussenzweig
MGI ID: MGI:4452369
Synonyms: IgH96k
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159173
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with 5' loxP and I-SceI site was inserted into the 3' Ighg1 switch region. Flp mediated recombination removed the neo cassette leaving the single loxP site. ES cells originally used to create this allele also contained Ightm3Mnz 96 kb upstream. (J:159173)
Generation of the Ightm4.1Mnz allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:159173 Bothmer A, et al., 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med. 2010 Apr 12;207(4):855-65
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory