Tg(CD19-Tnfsf7)#Rvl
Transgene Detail

Summary

• Symbol: Tg(CD19-Tnfsf7)#Rvl
• Name: transgene insertion, Rene A W van Lier
• MGI ID: MGI:4452498
• Synonyms: CD70-Tg, CD70^TG
• Transgene: Tg(CD19-Tnfsf7)#Rvl Location: unknown
• Alliance: Tg(CD19-Tnfsf7)#Rvl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD19-Tnfsf7)#Rvl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd70 (MGI:1195273)

• Mutation details: A genomic fragement including the 3 exons of the mouse Tnfsf7 gene was adjoined to the human CD19 promoter region. The CD19 promoter overexpressed Tnfsf7 in B cell specific manner. Two lines were created (lines 12 and 13). No line specified is denoted by *. (J:73129)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88620 Nolte MA, et al., B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol. 2004 Mar 15;172(6):3620-7
• All: 10 reference(s)