Cldn2^tm1Muto
Targeted Allele Detail

Summary

• Symbol: Cldn2^tm1Muto
• Name: claudin 2; targeted mutation 1, Shigeaki Muto
• MGI ID: MGI:4452519
• Synonyms: Cldn2^-
• Gene: Cldn2 Location: ChrX:138701577-138712135 bp, + strand Genetic Position: ChrX, 61.35 cM
• Alliance: Cldn2^tm1Muto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159379
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The coding sequence for 1 to 111 amino acids of the single exon was replaced with a neomycin resistance gene. (J:159379)

Generation of the Cldn2^tm1Muto allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn2 Mutation: 10 strains or lines available

References

• Original: J:159379 Muto S, et al., Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):8011-6
• All: 6 reference(s)