Casc3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Casc3^{tm1(KOMP)Vlcg}
• Name: exon junction complex subunit; targeted mutation 1, Velocigene
• MGI ID: MGI:4452843
• Synonyms: Casc3^Null
• Gene: Casc3 Location: Chr11:98700634-98724633 bp, + strand Genetic Position: Chr11, 62.68 cM
• Alliance: Casc3^{tm1(KOMP)Vlcg} page
• IMPC: Casc3 gene page

Mutation origin

• Mutant Cell Lines: 11788A-E8, 11788B-H10
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 21780bp between positions 98700693-98722472 of Chromosome 11 (Build GRCm39). The lacZ/neo insertion replaced the entire coding sequence (exons 1-11). (J:136110, J:240595)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Casc3 Mutation: 41 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)