Il33^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Il33^{tm1(KOMP)Vlcg}
• Name: interleukin 33; targeted mutation 1, Velocigene
• MGI ID: MGI:4452857
• Synonyms: Il33^-
• Gene: Il33 Location: Chr19:29902514-29938118 bp, + strand Genetic Position: Chr19, 24.56 cM, cytoband C2
• Alliance: Il33^{tm1(KOMP)Vlcg} page
• IMPC: Il33 gene page

Mutation origin

• Mutant Cell Lines: 12663E-A11, 12663E-H2
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 9443 bp between positions 29927074-29936516 of Chromosome 19 (Build GRCm39). Western blot and immunofluorescence analyses confirmed the complete lack of protein in the ovaries of homozygous mutant mice. (J:136110)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Il33 Mutation: 33 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 13 reference(s)