Atat1^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Atat1^{tm1(KOMP)Vlcg}
• Name: alpha tubulin acetyltransferase 1; targeted mutation 1, Velocigene
• MGI ID: MGI:4453011
• Synonyms: alphaTAT1^-
• Gene: Atat1 Location: Chr17:36208487-36220967 bp, - strand Genetic Position: Chr17, 18.75 cM, cytoband B3
• Alliance: Atat1^{tm1(KOMP)Vlcg} page
• IMPC: Atat1 gene page

Dilated lateral ventricles and abnormal dentate gyrus morphology in Atat1^{tm1(KOMP)Vlcg}/Atat1^{tm1(KOMP)Vlcg} brains

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: 14032A-B5, 14032A-C2, 14032A-D10
• Germline Transmission: Earliest citation of germline transmission: J:201922
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1 Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 9210bp between positions 36211715-36220924 of Chromosome 17 (Build GRCm39). The lacZ and floxed neomycin resistance cassette replaced all the coding exons. RT-PCR confirmed the absence of transcript expression in the testis, kidney, liver, lung, adrenal gland, prostate, spleen, small intestine, fat, pancreas, brain and heart. (J:136110, J:201922)

Strategy for the generation of the Atat1^tm1(KOMP)Vlcg allele

Expression

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Atat1 Mutation: 30 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 8 reference(s)