Cdh23^12J
Chemically induced Allele Detail

Summary

• Symbol: Cdh23^12J
• Name: cadherin related 23 (otocadherin); 12 Jackson
• MGI ID: MGI:4453135
• Synonyms: Cdh23^erl, Cdh23^nmf308, erl, erlong, NMF308
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^12J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation is a T to C transition at coding nucleotide 208, which is base pair 63 in exon 3, that results in replacement of serine by proline at amino acid position 70 (p.S70P). (J:174758, J:183808)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 281 strains or lines available

References

• Original: J:174758 Han F, et al., A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J. 2012 Feb;12(1):30-44
• All: 6 reference(s)