Ptch1^tm1Cklr
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm1Cklr
• Name: patched 1; targeted mutation 1, Charles Keller
• MGI ID: MGI:4453152
• Synonyms: Ptc1^F1-2m
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm1Cklr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159972
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Lox511 sites were inserted in the intron between exon 1C and exon 1B as well as in intron 2 just downstream of an frt flanked neomycin insert. The neomycin selection cassette was subsequently excised in mice by crossing to transgenic mice expressin Flp recombinase. (J:159972)

Tumor Data

List all tumor models in MMHCdb carrying Ptch1^tm1Cklr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:159972 Taniguchi E, et al., Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug;53(2):136-44
• All: 5 reference(s)