Ikbkb^tm2.1Mka
Targeted Allele Detail

Summary

• Symbol: Ikbkb^tm2.1Mka
• Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, Michael Karin
• MGI ID: MGI:4453210
• Synonyms: IKKbeta^delta
• Gene: Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
• Alliance: Ikbkb^tm2.1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88644
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon 3 in Ikbkb^tm2Mka was removed via cre-mediated recombination by breeding with Tg(Vil-cre)1Mka mice. Although this cre transgene is expressed in the small intestinal epithelial and colon epithelial cells, a small amount of cre recombination occurred in the testis resulting in germline transmission of the exon 3 deleted allele. (J:82995, J:88644)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkb Mutation: 56 strains or lines available

Notes

ES cell line = GS (Genome Systems).

References

• Original: J:88644 Egan LJ, et al., IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2452-7
• All: 5 reference(s)