Lrp5^tm1Mawa
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm1Mawa
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Matthew Warman
• MGI ID: MGI:4453217
• Synonyms: GN, Lrp5 G171V-Neo
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm1Mawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: lycine 170 of the targeted gene was converted to valine (equivalent to the human G171V missense mutation) via site-directed mutagenesis and a floxed neomycin selection cassette was placed in reverse transcriptional orientation in intron 2. (J:172746)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:172746 Cui Y, et al., Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun;17(6):684-91
• All: 1 reference(s)