Lrp5^tm2Mawa
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm2Mawa
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 2, Matthew Warman
• MGI ID: MGI:4453225
• Synonyms: AN, Lrp5 A214V-Neo
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm2Mawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: lanine 213 of the targeted gene was converted to valine (equivalent to the human A214V missense mutation) via site-directed mutagenesis and a floxed neomycin selection cassette was placed in reverse transcriptional orientation in intron 2. (J:172746)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:172746 Cui Y, et al., Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun;17(6):684-91
• All: 3 reference(s)