Xirp2^tm1Jl
Targeted Allele Detail

Summary

• Symbol: Xirp2^tm1Jl
• Name: xin actin-binding repeat containing 2; targeted mutation 1, Jim J-C Lin
• MGI ID: MGI:4453315
• Synonyms: mXinbeta^-, Xirp2^-
• Gene: Xirp2 Location: Chr2:67276343-67356964 bp, + strand Genetic Position: Chr2, 39.31 cM
• Alliance: Xirp2^tm1Jl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158491
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 6, intron 6 and a part of exon 7 were replaced with a LacZ-Neo cassette by homologous recombination. Northern blot and Western blot analysis revealed a complete loss of message and protein, respectively, in homozygous mice. (J:158491)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xirp2 Mutation: 163 strains or lines available

References

• Original: J:158491 Wang Q, et al., Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival. Circ Res. 2010 May 14;106(9):1468-78
• All: 5 reference(s)