Lhx2^tm1.1Lcar
Targeted Allele Detail

Summary

• Symbol: Lhx2^tm1.1Lcar
• Name: LIM homeobox protein 2; targeted mutation 1.1, Leif Carlsson
• MGI ID: MGI:4453328
• Synonyms: Lhx2^flox
• Gene: Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
• Alliance: Lhx2^tm1.1Lcar page

Hair follicles of tamoxifen-treated Lhx2^tm1.1Lcar/Lhx2^tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159209
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed and FRT flanked neo cassette was inserted between exons 2 and 3, and an additional loxP site was inserted within intron 1. The selection cassette was removed by flp mediated recombination. (J:159209)

Generation of the Lhx2^tm1.1Lcar allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx2 Mutation: 12 strains or lines available

References

• Original: J:159209 Tornqvist G, et al., Cyclic expression of lhx2 regulates hair formation. PLoS Genet. 2010;6(4):e1000904
• All: 4 reference(s)