Trim32^tm1Hdin
Targeted Allele Detail

Summary

• Symbol: Trim32^tm1Hdin
• Name: tripartite motif-containing 32; targeted mutation 1, Hao Ding
• MGI ID: MGI:4453461
• Gene: Trim32 Location: Chr4:65523223-65534475 bp, + strand Genetic Position: Chr4, 34.43 cM, cytoband C1
• Alliance: Trim32^tm1Hdin page

Trim32^tm1Hdin/Trim32^tm1Hdin mice show delayed and impaired skeletal muscle regeneration

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159937
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a splice acceptor, IRES and beta-geo cassette. Western blot analysis confirmed the absence of protein expression in the mouse embryonic fibroblasts. (J:184218)

Gene-targeting strategy for creating the Trim32^tm1Hdin null allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim32 Mutation: 27 strains or lines available

References

• Original: J:159937 Liu Y, et al., Regulation of the psoriatic chemokine CCL20 by E3 ligases Trim32 and Piasy in keratinocytes. J Invest Dermatol. 2010 May;130(5):1384-90
• All: 7 reference(s)