Gt(ROSA)26Sor^tm1.2Tiw
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1.2Tiw
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.2, Takao Iwawaki
• MGI ID: MGI:4453463
• Synonyms: ROSA26^{ERAI-LUCdeltaStop}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1.2Tiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An ER stress-activated indicator fused to luciferase preceded by an frt flanked neo cassette with an upstream loxP site and a STOP cassette with a downstream loxP site. Cre and flp mediated recombination removed the floxed neo cassette and STOP cassette. In vivo imaging confirmed luciferase expression in the whole body following ER stress. (J:159968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:159968 Hosoda A, et al., Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland. Biochem J. 2010 Jan 1;425(1):117-25
• All: 1 reference(s)