Arhgef4^tm1Taki
Targeted Allele Detail

Summary

• Symbol: Arhgef4^tm1Taki
• Name: Rho guanine nucleotide exchange factor 4; targeted mutation 1, Tetsu Akiyama
• MGI ID: MGI:4453566
• Synonyms: Asef^-
• Gene: Arhgef4 Location: Chr1:34717263-34851819 bp, + strand Genetic Position: Chr1, 13.34 cM
• Alliance: Arhgef4^tm1Taki page

Impaired endothelial cell sprouting from Arhgef4^tm1Taki/Arhgef4^tm1Taki aortas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159959
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A neo cassette was inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:159959)

Targeted disruption of the Arhgef4 gene generating the Arhgef4^tm1Taki allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef4 Mutation: 74 strains or lines available

References

• Original: J:159959 Kawasaki Y, et al., The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. J Biol Chem. 2010 Jan 8;285(2):1199-207
• All: 5 reference(s)