Kdm3a^tm1Jxu
Targeted Allele Detail

Summary

• Symbol: Kdm3a^tm1Jxu
• Name: lysine (K)-specific demethylase 3A; targeted mutation 1, Jianming Xu
• MGI ID: MGI:4453574
• Synonyms: Jmjd1a^-
• Gene: Kdm3a Location: Chr6:71565954-71609963 bp, - strand Genetic Position: Chr6, 32.18 cM
• Alliance: Kdm3a^tm1Jxu page

Low testis weight and sperm count in Kdm3a^tm1Jxu/Kdm3a^tm1Jxu mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159956
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 17 through 25 were replaced with a neo cassette. The absence of full length protein expression was confirmed by western blot analysis on testis extracts. Weak expression of a truncated peptide is detected by western blot analysis. (J:159956)

Generation of the Kdm3a^tm1Jxu allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm3a Mutation: 81 strains or lines available

References

• Original: J:159956 Liu Z, et al., Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem. 2010 Jan 22;285(4):2758-70
• All: 3 reference(s)