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Il22tm1Jcrd
Targeted Allele Detail
Summary
Symbol: Il22tm1Jcrd
Name: interleukin 22; targeted mutation 1, Jean-Christophe Renauld
MGI ID: MGI:4453827
Gene: Il22  Location: Chr10:118040847-118045952 bp, + strand  Genetic Position: Chr10, 66.67 cM
Alliance: Il22tm1Jcrd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155038
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCoding exons 1a, 1b, 2, and a part of exon 3 were replace with a neo cassette by homologous recombination. Absence of RNA and protein was confirmed by RT-PCR and ELISA. (J:155038)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il22 Mutation:  29 strains or lines available
References
Original:  J:155038 Kreymborg K, et al., IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007 Dec 15;179(12):8098-104
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory