Tg(MMTV-cre)FMam
Transgene Detail

Summary

• Symbol: Tg(MMTV-cre)FMam
• Name: transgene insertion F, Lothar Hennighausen
• MGI ID: MGI:4453858
• Synonyms: F-line, MC(F), Tg(MMTV-cre)22Mam
• Transgene: Tg(MMTV-cre)FMam Location: unknown
• Alliance: Tg(MMTV-cre)FMam page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(MMTV-cre)FMam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	MMTV

• Mutation details: This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. (J:67925)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/?	involves: 129P2/OlaHsd * FVB
cn2	Etv6^tm3(NTRK3)Sho/Etv6^+ Tg(MMTV-cre)FMam/0	involves: 129S1/Sv * FVB/N
cn3	Ctnnd1^tm1Abre/Ctnnd1^tm1Abre Tg(MMTV-cre)FMam/0	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/N
tg4	Tg(MMTV-cre)FMam/?	involves: FVB

Phenotypes:

Affected Systems	cn1	cn2	cn3	tg4
show or hide all annotated terms Sex:
cellular			√	√	√
increased submandibular gland apoptosis			√
maternal effect				√	√
digestive/alimentary system			√
abnormal major salivary gland morphology			√
abnormal sublingual gland morphology			√
abnormal submandibular gland morphology			√
abnormal submandibular gland physiology			√
increased submandibular gland apoptosis			√
endocrine/exocrine glands	√		√	√
abnormal major salivary gland morphology			√
abnormal sublingual gland morphology			√
abnormal submandibular gland morphology			√
abnormal submandibular gland physiology			√
increased submandibular gland apoptosis			√
abnormal mammary gland development	√
abnormal branching of the mammary ductal tree	√
abnormal mammary gland growth during lactation	√			√
abnormal mammary gland growth during pregnancy	√
abnormal mammary duct terminal end bud morphology	√
abnormal lacrimal gland morphology			√
hypolactation	√
integument	√			√
abnormal mammary gland development	√
abnormal branching of the mammary ductal tree	√
abnormal mammary gland growth during lactation	√			√
abnormal mammary gland growth during pregnancy	√
abnormal mammary duct terminal end bud morphology	√
hypolactation	√
mortality/aging		√	√
premature death		√
postnatal lethality, complete penetrance			√
neoplasm		√
increased chronic myelocytic leukemia incidence		√
reproductive system	√
abnormal mammary gland growth during pregnancy	√
vision/eye			√
abnormal lacrimal gland morphology			√

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-cre)FMam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:76553 Cui Y, et al., Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem. 2002 May 17;277(20):17830-5
• All: 21 reference(s)