Tg(MMTV-cre)FMam
Transgene Detail
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Symbol: |
Tg(MMTV-cre)FMam |
Name: |
transgene insertion F, Lothar Hennighausen |
MGI ID: |
MGI:4453858 |
Synonyms: |
F-line, MC(F), Tg(MMTV-cre)22Mam |
Transgene: |
Tg(MMTV-cre)FMam Location: unknown
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Alliance: |
Tg(MMTV-cre)FMam page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(MMTV-cre)FMam expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
virus |
MMTV |
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Mutation details: This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues.
(J:67925)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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MMTV
(virus)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:76553 Cui Y, et al., Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem. 2002 May 17;277(20):17830-5 |
All: |
21 reference(s) |
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