Hand2^tm1.2Zllr
Targeted Allele Detail

Summary

• Symbol: Hand2^tm1.2Zllr
• Name: heart and neural crest derivatives expressed 2; targeted mutation 1.2, Rolf Zeller
• MGI ID: MGI:4453961
• Synonyms: Hand2^delta
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm1.2Zllr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159210
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted to flank both coding exons. An frt-flanked pgk-neo cassette was included downstream of the 3' loxP site. Frt-mediated and Cre-mediated recombination removed the pgk-neo and deleted the transcription unit. (J:159210)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:159210 Galli A, et al., Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901
• All: 4 reference(s)