Mpzl3^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: Mpzl3^tm1(KOMP)Mbp
• Name: myelin protein zero-like 3; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:4454034
• Synonyms: Mpzl3^tm1(KOMP)Ucd
• Gene: Mpzl3 Location: Chr9:44966484-44988734 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Mpzl3^tm1(KOMP)Mbp page
• IMPC: Mpzl3 gene page

Mutation origin

• Mutant Cell Lines: DEPD00515_4_B05, DEPD00515_4_B06, DEPD00515_4_B08, DEPD00515_4_C05, DEPD00515_4_C06, DEPD00515_4_C07, DEPD00515_4_C08, DEPD00515_4_D05, DEPD00515_4_E05, DEPD00515_4_F07, DEPD00515_4_F08, DEPD00515_4_G05, DEPD00515_4_G08, DEPD00515_4_H05, DEPD00515_4_H08
• Germline Transmission: Earliest citation of germline transmission: J:210832
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 6431 starting at position 44973303 and ending at position 44979734 of Chromosome 9 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064, J:210832)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Mpzl3 Mutation: 33 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 2 reference(s)