Aire^tm3(cre)Mmat
Targeted Allele Detail

Summary

• Symbol: Aire^tm3(cre)Mmat
• Name: autoimmune regulator; targeted mutation 3, Mitsuru Matsumoto
• MGI ID: MGI:4454265
• Synonyms: Aire/Cre KI
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm3(cre)Mmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Aire^tm3(cre)Mmat expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aire (MGI:1338803)

• Mutation details: A cre recombinase-floxed neomycin resistance cassette was inserted into exon 1 of the Aire gene, such that expression was under control of the endogenous Aire promoter. The floxed neo cassette was spontaneously deleted, likely as a result of autonomous expression of cre from the Aire locus during early embryogenesis and/or spermatogenesis. (J:160217)

Generation of the Aire^tm3(cre)Mmat allele

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (mouse) Summary of all recombinase alleles driven by Aire. Comparative matrix view of recombinase activities Alliance mouse Aire gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 52 strains or lines available

References

• Original: J:160217 Nishikawa Y, et al., Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med. 2010 May 10;207(5):963-71
• All: 1 reference(s)