Cd226^tm1.1Cln
Targeted Allele Detail

Summary

• Symbol: Cd226^tm1.1Cln
• Name: CD226 antigen; targeted mutation 1.1, Marco Colonna
• MGI ID: MGI:4454325
• Synonyms: DNAM-1^-
• Gene: Cd226 Location: Chr18:89195091-89290353 bp, + strand Genetic Position: Chr18, 59.05 cM
• Alliance: Cd226^tm1.1Cln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159749
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons two and three, encoding the start site and first 129 amino acids, were replaced by a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:159749)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd226 Mutation: 34 strains or lines available

References

• Original: J:159749 Gilfillan S, et al., DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008 Dec 22;205(13):2965-73
• All: 18 reference(s)