Sall1^tm4.2Ryn
Targeted Allele Detail

Summary

• Symbol: Sall1^tm4.2Ryn
• Name: spalt like transcription factor 1; targeted mutation 4.2, Ryuichi Nishinakamura
• MGI ID: MGI:4454454
• Synonyms: Sall1^delta
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^tm4.2Ryn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159449
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre mediated recombination removed exon 1 and the neo cassette. (J:159449)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Sall1^tm4.2Ryn/Sall1^tm4.2Ryn	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
renal/urinary system	√
abnormal kidney morphology	√
absent kidney	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 78 strains or lines available

References

• Original: J:159449 Yuri S, et al., Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression. Stem Cells. 2009 Apr;27(4):796-805
• All: 1 reference(s)