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Carm1tm2.1Mtb
Targeted Allele Detail
Summary
Symbol: Carm1tm2.1Mtb
Name: coactivator-associated arginine methyltransferase 1; targeted mutation 2.1, Mark T Bedford
MGI ID: MGI:4454543
Synonyms: CARM1KI
Gene: Carm1  Location: Chr9:21458163-21500763 bp, + strand  Genetic Position: Chr9, Syntenic
Alliance: Carm1tm2.1Mtb page
Small size of Carm1tm2.1Mtb/Carm1tm2.1Mtb fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159958
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitution in exon 3 results in the amino acid substitution of arginine to alanine at position 169 (R169A). Exons 2 and 3 are also floxed. Flp mediated recombination removed the neo cassette upstream of exon 2. The predicted product is expected to be kinase dead. (J:159958)
Generation of the knock-in Carm1tm2.1Mtb allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Carm1 Mutation:  94 strains or lines available
References
Original:  J:159958 Kim D, et al., Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 8;285(2):1147-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory