Carm1^tm2.1Mtb
Targeted Allele Detail

Summary

• Symbol: Carm1^tm2.1Mtb
• Name: coactivator-associated arginine methyltransferase 1; targeted mutation 2.1, Mark T Bedford
• MGI ID: MGI:4454543
• Synonyms: CARM1^KI
• Gene: Carm1 Location: Chr9:21458163-21500763 bp, + strand Genetic Position: Chr9, Syntenic
• Alliance: Carm1^tm2.1Mtb page

Small size of Carm1^tm2.1Mtb/Carm1^tm2.1Mtb fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159958
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted Mutations: Insertion, Nucleotide substitutions Mutation details: Nucleotide substitution in exon 3 results in the amino acid substitution of arginine to alanine at position 169 (R169A). Exons 2 and 3 are also floxed. Flp mediated recombination removed the neo cassette upstream of exon 2. The predicted product is expected to be kinase dead. (J:159958)

Generation of the knock-in Carm1^tm2.1Mtb allele

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Carm1 Mutation: 94 strains or lines available

References

• Original: J:159958 Kim D, et al., Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 8;285(2):1147-52
• All: 1 reference(s)