Tie1^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Tie1^tm1Geno
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1, Genoway
• MGI ID: MGI:4454546
• Synonyms: Tie1^neo
• Gene: Tie1 Location: Chr4:118328388-118347046 bp, - strand Genetic Position: Chr4, 54.67 cM
• Alliance: Tie1^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159507
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. (J:159507)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tie1 Mutation: 68 strains or lines available

References

• Original: J:159507 D'Amico G, et al., Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):207-9
• All: 4 reference(s)