Foxn1^tm1.1Dmsu
Targeted Allele Detail

Summary

• Symbol: Foxn1^tm1.1Dmsu
• Name: forkhead box N1; targeted mutation 1.1, Dong-Ming Su
• MGI ID: MGI:4454641
• Synonyms: FoxN1^fx
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^tm1.1Dmsu page

Thymic atrophy in tamoxifen treated Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159773
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Flp mediated recombination removed the neo cassette leaving exons 5 and 6 floxed. (J:159773)

Generation of the Foxn1^tm1.1Dmsu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:159773 Cheng L, et al., Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem. 2010 Feb 19;285(8):5836-47
• All: 10 reference(s)