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Foxn1tm1.1Dmsu
Targeted Allele Detail
Summary
Symbol: Foxn1tm1.1Dmsu
Name: forkhead box N1; targeted mutation 1.1, Dong-Ming Su
MGI ID: MGI:4454641
Synonyms: FoxN1fx
Gene: Foxn1  Location: Chr11:78248403-78277384 bp, - strand  Genetic Position: Chr11, 46.74 cM
Alliance: Foxn1tm1.1Dmsu page
Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159773
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Flp mediated recombination removed the neo cassette leaving exons 5 and 6 floxed. (J:159773)
Generation of the Foxn1tm1.1Dmsu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:  106 strains or lines available
References
Original:  J:159773 Cheng L, et al., Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem. 2010 Feb 19;285(8):5836-47
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory