Adamts4^tm1Dqp
Targeted Allele Detail

Summary

• Symbol: Adamts4^tm1Dqp
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 4; targeted mutation 1, Duanqing Pei
• MGI ID: MGI:4454664
• Gene: Adamts4 Location: Chr1:171077990-171088206 bp, + strand Genetic Position: Chr1, 79.28 cM
• Alliance: Adamts4^tm1Dqp page

Abnormal Purkinje cell morphology in the Sparcl1^tm1Pmc/Sparcl1^tm1Pmc and Adamts4^tm1Dqp/Adamts4^tm1Dqp cerebellum

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• No description available.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Adamts4^tm1Dqp/Adamts4^tm1Dqp	involves: 129X1/SvJ * C57BL/6J

Phenotypes:

Affected Systems	hm1
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nervous system	√
abnormal Purkinje cell morphology	√
gliosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts4 Mutation: 49 strains or lines available

References

• Original: J:159752 Weaver MS, et al., Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. J Biol Chem. 2010 Feb 19;285(8):5868-77
• All: 1 reference(s)