Appl1^tm1.2Test
Targeted Allele Detail

Summary

• Symbol: Appl1^tm1.2Test
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; targeted mutation 1.2, Joseph Testa
• MGI ID: MGI:4454678
• Gene: Appl1 Location: Chr14:26640943-26692567 bp, - strand Genetic Position: Chr14, 16.09 cM, cytoband B
• Alliance: Appl1^tm1.2Test page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159889
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated recombination removed exon 5. This allele also lacks the neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:159889)

Generation of the Appl1^tm1.1Test and Appl1^tm1.2Test alleles

Expression

In Mice Carrying this Mutation:

56 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl1 Mutation: 47 strains or lines available

References

• Original: J:159889 Tan Y, et al., Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem. 2010 Feb 26;285(9):6377-89
• All: 3 reference(s)