Il6ra^tm1Saj
Targeted Allele Detail

Summary

• Symbol: Il6ra^tm1Saj
• Name: interleukin 6 receptor, alpha; targeted mutation 1, Simon A Jones
• MGI ID: MGI:4454682
• Synonyms: CD126^-
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^tm1Saj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159479
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced with a construct containing an IRES, lacZ, polyadenylation sequence, and neo cassette. The absence of protein expression was confirmed by flow cytometry. (J:159479)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:159479 Jones GW, et al., Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010 Feb 15;184(4):2130-9
• All: 8 reference(s)