Lrp4^tm2Her
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm2Her
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 2, Joachim Herz
• MGI ID: MGI:4455050
• Synonyms: Lrp4^-
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm2Her page

Unilateral and bilateral kidney agenesis in Lrp4^tm2Her/Lrp4^tm2Her mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1, which encodes the signal peptide and the initiating ATG, was replaced with a neomycin stop cassette. No residual functional protein can be generated. (J:156471, J:160547)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 98 strains or lines available

References

• Original: J:156471 Ohazama A, et al., A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):92-7
• All: 4 reference(s)