Fas^theo
Chemically induced Allele Detail

Summary

• Symbol: Fas^theo
• Name: Fas cell surface death receptor; theoden
• MGI ID: MGI:4455060
• Synonyms: ENU4AT:050, Fas^The
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^theo page

Mutation origin

• Strain of Origin: C57BL/6JAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation, in exon 4 of the gene (ENSMUSE00000144910), has been identified as a G to A transition at nucleotide position 422 of the cDNA sequence; it is predicted to result in replacement of cysteine by tyrosine at amino acid position 139 of the protein (C139Y). (J:104190)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

Notes

The mutation is a loss-of-function point mutation at the Fas gene that results in high titers of antinuclear Ab (ANA+) in the mice, as well as an accumulation of double-negative T cells in the periphery as the mice age; in these respects, they are very similar to the Faslpr/lpr mice strain (L. Tze and C. Goodnow, unpublished observations).

References

• Original: J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014
• All: 2 reference(s)