Tg(Neurog1-cre)1Jejo
Transgene Detail

Summary

• Symbol: Tg(Neurog1-cre)1Jejo
• Name: transgene insertion 1, Jane E Johnson
• MGI ID: MGI:4455179
• Synonyms: N1⁴⁵⁷-Cre, Neurog1⁴⁵⁷-Cre, Ngn1::Cre
• Transgene: Tg(Neurog1-cre)1Jejo Location: unknown
• Alliance: Tg(Neurog1-cre)1Jejo page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Neurog1-cre)1Jejo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog1 (MGI:107754)

• Mutation details: The Neurog1 coding region in the BAC RP23 457E22 was replaced by recombineering methods with the coding sequence for cre recombinase. Pronuclear injection of the construct into (C57BL/6J x SJL/J)F1 fertilized eggs was used to generated transgenic mice. Founder mice were subsequently established. The transgenic mice were then bred to outbred ICR mice. When crossed with a reporter strain, cre activity mimics the endogenous gene expression patterns in specific populations of interneurons and some motor neurons in the neural tube between embryonic days 10-13. Also, Cre recombination occurs in Neurog1 lineages that include subpopulations of neurons in the olfactory bulb, hippocampus, cortex, thalamus, midbrain, cerebellum, and dorsal root and cranial ganglia. (J:160255)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog1 (mouse) Summary of all recombinase alleles driven by Neurog1. Comparative matrix view of recombinase activities Alliance mouse Neurog1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:160255 Quinones HI, et al., Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages. Dev Biol. 2010 Apr 15;340(2):283-92
• All: 13 reference(s)