Sp8^tm2.1Aman
Targeted Allele Detail

Summary

• Symbol: Sp8^tm2.1Aman
• Name: trans-acting transcription factor 8; targeted mutation 2.1, Ahmed Mansouri
• MGI ID: MGI:4455192
• Gene: Sp8 Location: Chr12:118810064-118816311 bp, + strand Genetic Position: Chr12, 63.48 cM
• Alliance: Sp8^tm2.1Aman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160653
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstrea of exon 3. Flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. (J:160653)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp8 Mutation: 29 strains or lines available

References

• Original: J:160653 Zembrzycki A, et al., Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev. 2007;2:8
• All: 2 reference(s)