Erbb3^m3329Ddg
Chemically induced Allele Detail

Summary

• Symbol: Erbb3^m3329Ddg
• Name: erb-b2 receptor tyrosine kinase 3; mutation 3329, David D Ginty
• MGI ID: MGI:4455202
• Synonyms: ErbB3^I449S
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^m3329Ddg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU (N-ethyl-N-nitrosourea) mutagenesis generated a single point mutation in exon 13 (T1346G), creating a single amino acid substitution of serine for isoleucine at position 449 (I449S). (J:160880)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 48 strains or lines available

References

• Original: J:159834 Merte J, et al., A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010 Apr 21;30(16):5767-75
• All: 2 reference(s)