Sema3a^m808Ddg
Chemically induced Allele Detail

Summary

• Symbol: Sema3a^m808Ddg
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; mutation 808, David D Ginty
• MGI ID: MGI:4455203
• Synonyms: Sema3A^K108N
• Gene: Sema3a Location: Chr5:13175381-13652533 bp, + strand Genetic Position: Chr5, 4.31 cM
• Alliance: Sema3a^m808Ddg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion at position that results in the amino acid substitution of asparagine for lysine at position 108 (K108N). The protein product is predicted to poorly interact with the Npn-1/PlexA holoreceptor. (J:159834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema3a Mutation: 48 strains or lines available

References

• Original: J:159834 Merte J, et al., A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010 Apr 21;30(16):5767-75
• All: 9 reference(s)