Pnn^tm1.1Sps
Targeted Allele Detail

Summary

• Symbol: Pnn^tm1.1Sps
• Name: pinin; targeted mutation 1.1, Stephen P Sugrue
• MGI ID: MGI:4455341
• Synonyms: Pnn^2f, Pnn^flox
• Gene: Pnn Location: Chr12:59113705-59120803 bp, + strand Genetic Position: Chr12, 26.0 cM
• Alliance: Pnn^tm1.1Sps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123288
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 2 and a floxed neo cassette was inserted in intron 8 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exons 3 - 8 floxed. (J:123288)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnn Mutation: 31 strains or lines available

References

• Original: J:123288 Joo JH, et al., Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice. Dev Dyn. 2007 Aug;236(8):2147-58
• All: 5 reference(s)