Gdnf^tm1.1Neas
Targeted Allele Detail

Summary

• Symbol: Gdnf^tm1.1Neas
• Name: glial cell line derived neurotrophic factor; targeted mutation 1.1, Neil A Shneider
• MGI ID: MGI:4456155
• Synonyms: GDNF^FLOX
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^tm1.1Neas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160727
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette was inserted upstream of a modified exon 3 in which the coding sequence was floxed. Flp mediated recombination removed the neo cassette leaving the coding sequence floxed. (J:160727)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 19 strains or lines available

References

• Original: J:160727 Shneider NA, et al., Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Neural Dev. 2009;4:42
• All: 5 reference(s)