Acd^tm1.1Cek
Targeted Allele Detail

Summary

• Symbol: Acd^tm1.1Cek
• Name: adrenocortical dysplasia; targeted mutation 1.1, Catherine Keegan
• MGI ID: MGI:4456177
• Synonyms: Acd^tm1.1Tdl, TPP1^F
• Gene: Acd Location: Chr8:106424789-106427748 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Acd^tm1.1Cek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160503
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 8. Flp mediated recombination removed the neo cassette leaving exons 3 through 8 floxed. (J:160503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acd Mutation: 22 strains or lines available

References

• Original: J:160503 Kibe T, et al., Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010 Feb;30(4):1059-66
• All: 3 reference(s)