Acd^tm1.2Cek
Targeted Allele Detail

Summary

• Symbol: Acd^tm1.2Cek
• Name: adrenocortical dysplasia; targeted mutation 1.2, Catherine Keegan
• MGI ID: MGI:4456178
• Synonyms: Acd^tm1.2Tdl, TPP1^DEL
• Gene: Acd Location: Chr8:106424789-106427748 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Acd^tm1.2Cek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160503
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 3 through 8 from Tpp1^tm1.1Tdl. The predicted protein is expected to be severely truncated containing the N-terminal 79 amino acids and 17 out-of-frame amino acids prior to a stop codon. (J:160503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acd Mutation: 22 strains or lines available

References

• Original: J:160503 Kibe T, et al., Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010 Feb;30(4):1059-66
• All: 1 reference(s)