Gpx3^tm1Hjco
Targeted Allele Detail

Summary

• Symbol: Gpx3^tm1Hjco
• Name: glutathione peroxidase 3; targeted mutation 1, Harvey J Cohen
• MGI ID: MGI:4456189
• Gene: Gpx3 Location: Chr11:54793680-54801213 bp, + strand Genetic Position: Chr11, 32.13 cM, cytoband B3-B5
• Alliance: Gpx3^tm1Hjco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159745
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the 3' portion of exon 2 through exon 5. The absence of protein was confirmed by immunohistochemistry on kidney samples. (J:159745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx3 Mutation: 37 strains or lines available

References

• Original: J:159745 Olson GE, et al., Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. Am J Physiol Renal Physiol. 2010 May;298(5):F1244-53
• All: 5 reference(s)