Tg(AMH-Fshr*D580H)#Hht
Transgene Detail

Summary

• Symbol: Tg(AMH-Fshr*D580H)#Hht
• Name: transgene insertion, Ilpo Huhtaniemi
• MGI ID: MGI:4456198
• Synonyms: mFshr^D580H, Tg(AMH-FSHR^D580H)
• Transgene: Tg(AMH-Fshr*D580H)#Hht Location: unknown
• Alliance: Tg(AMH-Fshr*D580H)#Hht page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(AMH-Fshr*D580H)#Hht expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fshr (MGI:95583)	Transgene codes for protein with aspartic acid to histidine mutation.

• Mutation details: The transgene contains a 3.6 kb human AMH promoter, and a murine Fshr with Asp580His mutation. Line number 4 and 14 were used in the study. mRNA of the transgenes was expressed in the ovaries and testes. The expression level of the transgene was similar to that of the endogenous mFshr in the ovaries. The severity of the abnormalities detected in ovaries, adrenal gland, pituitary gland and mammary gland correlated with the ovarian transgenic expression level. (J:160015)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160015 Peltoketo H, et al., Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Endocrinology. 2010 Apr;151(4):1872-83
• All: 1 reference(s)