Tg(AMH-Fshr*D580H)14Hht
Transgene Detail

Summary

• Symbol: Tg(AMH-Fshr*D580H)14Hht
• Name: transgene insertion 14, Ilpo Huhtaniemi
• MGI ID: MGI:4456199
• Synonyms: mFshr^D580H, Tg(AMH-FSHR^D580H)
• Transgene: Tg(AMH-Fshr*D580H)14Hht Location: unknown
• Alliance: Tg(AMH-Fshr*D580H)14Hht page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(AMH-Fshr*D580H)14Hht expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fshr (MGI:95583)	Transgene codes for protein with aspartic acid to histidine mutation.

• Mutation details: The transgene contains a 3.6 kb human AMH promoter, and a murine Fshr with Asp580His mutation. Line number 14 was used in the study of mRNA and hormone level. mRNA of the transgenes was expressed in the ovaries and testes. The expression level of the transgene was similar to that of the endogenous mFshr in the ovaries. The severity of the abnormalities detected in ovaries, adrenal gland, pituitary gland and mammary gland correlated with the ovarian transgenic expression level. (J:160015)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(AMH-Fshr*D580H)14Hht/0	involves: FVB/N

Phenotypes:

Affected Systems	tg1
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homeostasis/metabolism	√
increased circulating estradiol level	√
decreased circulating follicle stimulating hormone level	√
decreased circulating luteinizing hormone level	√
increased circulating prolactin level	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160015 Peltoketo H, et al., Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Endocrinology. 2010 Apr;151(4):1872-83
• All: 2 reference(s)