Abhd5^tm1.1Rze
Targeted Allele Detail

Summary

• Symbol: Abhd5^tm1.1Rze
• Name: abhydrolase domain containing 5; targeted mutation 1.1, Rudolf Zechner
• MGI ID: MGI:4456205
• Synonyms: Cgi-58^-
• Gene: Abhd5 Location: Chr9:122180681-122210589 bp, + strand Genetic Position: Chr9, 73.03 cM, cytoband F4
• Alliance: Abhd5^tm1.1Rze page

Small size, glossy dry skin, and necrotic tail tip in Abhd5^tm1.1Rze/Abhd5^tm1.1Rze mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160725
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed exons 4 through 7 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on carcass lipid droplet extracts. (J:160725)

Targeting strategy and generation of the Abhd5^tm1.1Rze allele

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd5 Mutation: 20 strains or lines available

References

• Original: J:160725 Radner FP, et al., Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem. 2010 Mar 5;285(10):7300-11
• All: 2 reference(s)